Locations

 

Paris

Hosted at the ICM

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Berlin

Hosted at the Hiesinger Lab

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Research focus

Diversity is a beautiful thing and unity is a powerful thing. Put them together, and what do you get? You get the most beautiful and powerful of all things: evolution! Much like human beings, cells of the nervous system are exquisitely diverse. They have diverse shapes and perform diverse functions. Yet, also like humans, underneath this bewildering diversity lies a profound unity: the genome. How can exactly the same genome produce so many different cells? The answer is that it depends on how a cell interprets its genome.

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From the blog

A new mechanism for old brain wiring pair!

We have discovered a divergent molecular and cellular mechanism regulating the activity of the Robo axon guidance receptor in the fly brain suggesting that the organizational principles of neuronal circuit wiring differ between the brain and the spinal cord. Robo receptors are crucial regulators of circuit wiring in the mammalian brain, and this discovery may be relevant in that context as well. You can read all about it at here!

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Move to Paris

Our laboratory is moving from VIB in Leuven, Belgium to ICM (Brain & Spine Institute) in Paris, France. Throughout this year we will be slowly closing our operations in Leuven and starting up in Paris. In 2017 our move will be finished.

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We discovered a new regulatory mechanism

Our team has recently discovered a previously unknown mechanism that is highly conserved between species and which regulates neurogenesis through precise temporal control of the activity of a family of proteins essential for brain development: the proneural proteins. This mechanism, a simple reversible chemical modification, is critical for the production of a sufficient number of neurons, their differentiation and the development of the nervous system.

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